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Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOEnbspgene has three alleles such as APOEnbspε3 APOEnbspε4nbspand APOEnbspε2. It is located on human chromosome 19q13.
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Sialic acid aldolases or N-acetylneuraminate lyases catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature N-acetylneuraminate lyase mainly occurs in pathogens.
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MW 960.8 Da, Purity >95%. Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC₅₀ values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.
BNP and NT-proBNP are separated from precursor molecule proBNP via proteolytic processing The BNP and NT-proBNP level in blood are proportional to the severity of cardiac dysfunction They can be used for diagnosis of congestive heart failure (CHF)
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